Conference Schedule

Day1: July 5, 2018

Keynote Forum

Biography

Director, Analytical Development (AD), Vaccine Production Program (VPP), Vaccine Research Center (VRC/NIAID/NIH).

The goal of the Vaccine Production Program is to efficiently translate candidate research vaccines and monoclonal antibodies into materials for proof-of-concept clinical trials and to enable advanced development and licensure by partners. The VPP is responsible for process design and development, clinical good manufacturing practices (cGMP) manufacturing, pre-clinical safety testing, and regulatory activities for all VRC products.

Abstract

Western, Eastern, and Venezuelan equine encephalitis viruses, vector-borne alphaviruses of the Togaviridae family, are endogenous to equines of the Americas, but are also transmissible to humans by infected mosquitoes, causing frequent outbreaks and occasional epidemics. In humans, morbidity ranges from mild to severe with permanent neurological impairment, and mortality can be as high as 33%. Current approaches to vaccine development, VLPs are entities produced from host cells carrying recombinant DNA constructs in which the only viral genes resident are those essential to assemble a virus particle that faithfully mimics the native virus structure.

To assess WEVEE VLPs as potential vaccines in human clinical trials, the Vaccine Production Program has developed manufacture-amenable production, purification and formulation methods that generate a stable VLP drug substance. To evaluate the quality and quantity of VLPs throughout these processes, multiple analytical assays have been developed. This presentation details the development of a high throughput and high sensitivity purity determination method.

  The assay can evaluate purified VLPs in a concentration range of 20 to 249 µg/mL for VEE and 20 to 250 µg/mL for WEE, EEE VLPs.  Intra-analyst repeatability was determined to be <2% RSD, with inter-day repeatability RSD of <2%.  Specificity of the assay was established with 70-90% recovery in final formulation buffer for VEE, EEE and WEE VLPs. Optimizing the dye conjugation step yielded increased VLP signal substantially, but also increased system peak signal modestly between 20-25 kDa, resulting in a 26-200 kDa assay range. Further this assay was used to characterize all three vaccines lot to lot variations during manufacturing.

 

 

Biography

Jun Zhang is the Associate Professor of Harbin Institute of Technology (HIT) in China. His research interest focus on biological wastewater treatment, membrane techniques for wastewater reuse. He has published above 50 SCI papers and 5 approved Chinese patents during the recent years. As the executive chairman, co-organize the 2015 IWA Water Reclamation and Reuse Conference. His research interests are biological wastewater treatment, sludge reduction, resource and energy recovery from sewage sludge based on membrane separation techniques.

Abstract

Membrane bioreactor (MBR) processes are among the most economic and promising technologies for domestic and industrial wastewater treatment. Nevertheless, the ongoing requirements of excess sludge treatment/disposal and membrane fouling mitigation are major obstacles to the wide application of MBR. Using worm predation to reduce excess sludge is a potentially effective ecological technology of sludge reduction. Thus, a novel worm-fi xing bed reactor with special porous carrier and combined aeration system was designed to investigate the sludge reduction induced by worms. Meanwhile, the introduction of worm-fi xing bed to MBR could induce the changes of sludge properties which further alleviate the membrane fouling. Correspondingly, the integrated system (MBR-SSBWR) was composed of MBR and worm-fi xing reactor achieving signifi cant wastewater treatment effi ciency, sludge reduction and membrane fouling mitigation simultaneously. The results showed that total sCOD and NH4+-N treatment effi ciencies of 93.62 % and 96.2% were achieved in the integrated system. Regarding the sludge yields in conventional activated sludge (CAS) process, the sludge reduction percentages of 89% was observed in MBR-SSBWR system, in which an additional sludge reduction of 18.2 % was resulted from sludge predation. Soluble microbial products (SMP) and extracellular polymeric substances (EPS) were identifi ed as the key membrane foulants for the membrane process. During the operation time of 100 days, the transmembrane pressure (TMP) in the combined system was maintained less than 5 kPa, while the fi nal TMP in the Control MBR increased to 30 kPa. Due to the worm predation, the reduced amount of EPS was far more than the increased amount of SMP leading to a signifi cant decrease of protein-like substances which were dominant in the membrane foulants.

Tracks

  • Recent Developments in Separation Techniques | Recent Upgrades in Sample Preparation Process | Chromatography | Desalination & Wastewater Treatment Techniques | Separation Techniques in Environmental Chemistry
Location: Sylt 4-5
Speaker

Martin Schimpf

Boise State University, USA

Chair

Speaker

Fawzi Banat

Khalifa University, UAE

Co Chair

Biography

Dr Dietmar Schwahn is a senior scientist at the Forschungs-Neutronenquelle Heinz Maier-Leibnitz of the Technical University of Munich. His research interests are Neutron scattering techniques, phase behaviour of polymer blends and supercritical liquids, biomineralisation, process of wastewater desalination.

Abstract

Formation of aggregates caused by the interaction of organic and inorganic molecules, in particular those involved in the formation of calcium phosphate minerals, have strong negative influence on membrane permeability in reverse osmosis (RO) wastewater desalination.  A better understanding of the origin of these aggregates is needed. Small-angle neutron scattering (SANS) along with the technique of contrast variation is a strong tool in this field as it is a non-destructive technique allowing quantitative analysis on microscopic length scales between 1 nm and m as well as distinction between organic and inorganic components [1,2]. One of our goals is the realization of in-operando SANS experiments on RO desalination at close to realistic conditions. For this purpose we developed a cell for real-time SANS experiments simulating the process of RO-wastewater desalination up to 25 bar [3]. It is shown that the scattering from RO membranes is very strong and dominating. Membrane performance was determined in parallel to SANS by measuring water permeability and rejection. In this talk I will give a short description of the in-operando equipment followed by presentation of SANS data on the morphology of TFC RO membranes in particular of the polyamide active layer, as well as recent results from in-situ desalination SANS contrast variation experiments. 

References:

  1. V. Pipich et al., Langmuir 29, 7607 (2013).
  2. Y. Dahdal et al. Langmuir 30, 15072 (2014).
  3. D. Schwahn, et al. Desalination 405, 40 (2017).

Biography

Miloš Netopilík has completed his PhD at the age of 30 years from Institute of Macromolecular Chemistry and postdoctoral studies from Virginia Polytechnic Institute and Technical University. Now, he works in Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic and works in the theory of separation. He has published more than 68 papers in reputed journals.

Abstract

The equilibrium model is based on the concept of theoretical plate on which the equilibrium is formed between molecules of the analyte moving together with MP and those anchored on the surface by enthalpic attractive forces or penetrated into the pores by entropic process basically of Brownian diffusion into pores of the stationary phase (SP). However, the flow-rate, necessary to reach a good resolution, is by far lower than one would expect from that, necessary to reach a good equilibrium. Two kinetic processes, viz., tortuous and obstructed flow of eluent through and around the particles of packing and the flow profile in the mobile phase whose dispersive effect is controlled by transverse diffusion, may combine to reduce band broadening (imperfect resolution). To avoid it, the individual molecule has to sample the complete range of linear flow velocities in a random way as it moves along the column; this is achieved by transverse diffusion. This is shown on analyses of several polystyrene standards. 

Biography

More than 10 years PhD Dalnova works in the field of chemical diagnostics of metal-containing raw materials. The main scientific results include research in the field of development and creation of highly efficient sorbents of toxic elements, precious and rare-earth metals, studying the sorption properties and characteristics of the sorbents obtained, assessing the suitability of their use in improving analytical methods for various metal-containing objects.

Research Interests:

Separation and preconcentration of trace elements; synthesis of sorbents; recycled, secondary, technogenic raw materials; precious metals, rare earth metals; atomic absorption spectrometry, atomic emission spectrometry, chemical-spectral analysis.

 

Abstract

A comprehensive study of waste electrical and electronic equipment (WEEE) as a source of precious elements in the environment was conducted. The analytical possibilities and limitations of HR CS ETAAS have been explored, ways of overcoming existing limitations have been developed, both in the direction of instrumental leveling of interfering effects, and in the part of chemical transformation of the sample, including the separation of analytes and matrix by the selective sorbents developed by us. It is shown that the use of new complex-forming polymeric aminothioether sorbents in the analytical control of WEEE makes it possible to determine selectively and accurately both valuable components in a wide range of concentrations. For the study, two analytical methods, widely used and having a long record of application in analytical chemistry, atomic absorption* and atomic emission** analysis, were selected. A study of analytical capabilities has been carried out and an analysis technique has been developed using the latest instrument modifications of high-resolution spectrometers, an electronic recording and control system, a multielement, and a variety of operating modes. With their help, specific methods for analyzing selected objects with improved metrological characteristics were created. The authors gratefully acknowledge the financial support of Russian Science Foundation (16-13-10417 in part*) and Russian Foundation for Basic Research (16-03-00843 in part**).

Biography

Vasilina Eskina works as research scientist of physicochemical analysis methods laboratory of Quality and analytics department of State Scientific-Research and Design Institute of Rare-Metal Industry "Giredmet" JSC and is a postgraduate of NUST "MISIS" in the field of analytical chemistry (the last year of study). Eskina's scientific activity is focused on investigation of analytical capabilities of atomic-spectral analysis methods, use of synthesized sorbents for high-purity substances and secondary raw materials, development of highly efficient analytical techniques with high metrological characteristics. Author of more than 10 articles and 3 patents of the Russian Federation in the field of analytical chemistry and sorption.

Research Interests:

Separation and preconcentration of trace elements; recycled, secondary, technogenic raw materials; exhausted automobile catalysts; incinerator waste emissions; road dust; precious metal chemistry; toxic elements; atomic absorption spectrometry, atomic emission spectrometry, chemical-spectral analysis.

 

Abstract

Control of the waste’s chemical composition for the content of precious metals and toxic elements is an important part of any research accompanying reprocessing and disposal, as well as eco-analytical monitoring of natural objects are affected by waste. This research is related to the development and combined use of atomic spectral methods for analysis of metal-containing waste: atomic absorption and atomic emission, both in instrumental form and with sorption concentrating by a group of sulfur, nitrogen containing new type sorbents. The study is aimed at determining platinum metals (Pd, Pt, Rh) and toxic elements (As, Bi, Cd, Pb, Sb, Se and Te) in wastes. It is shown that platinum metals can be determined directly by the HR CS GFAAS method due to the high resolution of the spectrometer, despite the macro contents of the matrix elements. Macrocontains of matrix elements make it diffi cult to determine ecotoxic elements’s microcontains by direct instrumental analysis. The most effective approach to solving this problem is the use of advanced synthesized by the authors S,N-containing heterochain sorbents possessing unique properties for group separation and concentration of toxic elements. Kinetic features of the toxic elements’s sorption and properties of the synthesized sorbent depending on solution’s acidity are explored. The sorbent is tested for separation and group concentration of ecotoxic elements in presence of macrocomponents of secondary raw materials for their subsequent determination in the range n • 10-6 - n • 10-4 %wt by HR CS GFAAS and OES-ICP.The authors gratefully acknowledge the fi nancial support of Russian Science Foundation (16-13-10417).

Biography

Dr. Zhang Jinlan is a professor of  pharmaceutical analysis of Insititute of Materia Medica,Chinese Academy of Medical Sciences. Prof. Zhang has more than 90 publications, and received several awards. She was chosen to be in the 2009 New Century Talent Plan by the Chinese Ministry of Education. Prof. Zhang also serves numerous titles such as Committee members of Chinese MS Society (CMMS) Committee for Organics, Authorized Laboratory Auditor for the World Anti-Doping Agency (WADA), etc. Her research interests include method development and standardization for active ingredients in herbal medicine, DMPKT of new drugs, and metabolomics based mass spectrometry.

Research Interests:

  • Method development and standardization for active ingredients in herbal medicine.
  • Metabolism of herbal medicine and DMPKT of new drugs.
  • Metabolomics based mass spectrometry.

Abstract

A novel approach known as “database based dynamic target metabolomics”, from untargeted recognition and identification to targeted quantification for metabolites in bio-fluid samples on the basis of metabolomic database were developed. The RP-UHPLC/MS and HILIC-UHPLC/MS system were performed for untargeted lipid and polar metabolite profiling, respectively. Metabolite peak features in RP and HILIC systems were assigned by molecular feature extract to remove interference from other fragment ions. HRMS/MS data of assigned metabolites were processed by the Lipid Maps database to identify the lipid compounds and the METLIN QTOF MS/MS database and PCDL database for the polar metabolites in different biological samples. The identified metabolites both lipid and polar compounds were assigned to generate the targeted lists for quantification, and the in-home PCDL HRMSMS database of targeted metabolites for different bio-sample was established. This approach is suitable for modern metabolomic research which takes the advantages of the untargeted recognition and identification ability and the targeted accuracy quantification, with the dynamic and automatic characterization. 

Biography

Dr. Jun Zhang is the Associate Professor of Harbin Institute of Technology (HIT) in China. His research interest focus on biological wastewater treatment, membrane techniques for wastewater reuse. He has published above 50 SCI papers and 5 approved Chinese patents during the recent years. As the executive chairman, co-organize the 2015 IWA Water Reclamation and Reuse Conference.

Abstract

A hollow-fiber membrane bioreactor (MBR) was integrated with a microbial fuel cell (MFC) to develop a novel system of MFC-MBR based on the utilization of electricity recovered by the MFC for wastewater treatment improvement and membrane fouling mitigation in the MBR. In this system, a maximum power density of 2.18W/m3 and an average voltage output of 0.15V were achieved at an external resistance of 50 Ω. The removal efficiencies of COD, ammonia nitrogen (NH4+-N) and total nitrogen (TN) in the MFC-MBR were improved by 4.4%, 1.2% and 10.3%, respectively. It is worth noting that, in addition to reducing the deposition of sludge on the membrane surface by the electric field force, the MFC-MBR also alleviated the membrane fouling by sludge modification. Compared with the control MBR (C-MBR), less loosely bound extracellular polymeric substances (LB-EPS), lower SMPp/SMPc ratio, more homogenized sludge flocs and less filamentous bacteria were obtained in the MFC-MBR, which improved the dewaterability and filterability of the sludge. The cake layer on the membrane formed by the modified sludge was more porous with lower compressibility, significantly enhancing the membrane filterability. The MFC-MBR system was effective in membrane fouling mitigation with efficient wastewater treatment and energy recovery, demonstrating the feasibility of the minute electricity generated by the MFC for membrane fouling alleviation in the MBR.

Biography

Dipl.-Ing. Su Xu is an instructor of Environmental engineering in Xiamen University of Technology and got her Dipl.-Ing. degree from TU-Cottbus Germany. Now she is a PhD student of National Tsing Hua University.

Research Interests:

Environmental engineering; Energy technique; separation techniques

 

Abstract

MnO2 has been widely applied as active additives in capacitive deionization (CDI) but there is no unambiguous conclusion made yet regarding which MnO2 phase would lead the highest CDI performance. To answer this question, different MnO2 phases (α,β,γ,and δ phase) were synthesized and associated to activated carbon supports to examine their CDI performances (percentage difference in the conductivity) in different pH by the simple batch mode method. Results collected from alkalimetric-acidimetric titration revealed that the deionization efficiency decreased proportionally with increasing surface charge (degree of ionization of surface hydroxyl groups) of MnO2 additives. Importantly, this correlation was independent to the pH and the MnO2 phases. Following electric impedance spectroscopy analyses clearly indicated this correlation is realized as a fact that a highly charged surface would induce a high resistance in the diffusion layer and hence conversely inhibit the access of foreign ions in CDI process. As a result, applied bias in CDI process is mainly to allow foreign ions to overcome this resistance, instead of to attract and accommodate them. Based on our results, the discrepancy in CDI efficiency resulting from different MnO2 phases might be simply attributed to structure induced surface charge effect where different MnO2 phases possess their unique surface charge pattern.

Keywords: capacitive deionization; separation of ionic compounds; seawater desalination; surface charge effect

Biography

Devender Thayar Seshadri is a Manager of Analytical Development Laboratory in R&D of Indofil Industries Limited. He has been working in analysis of Agrochemicals and Specialty Chemicals for more than 15 years. He has done his doctoral work in the synthesis, characterization and applications of conducting polymers and their composites from U.D.C.T.-Mumbai. He is currently also guiding doctoral students and affiliated with various Universities in India as an Industry Co-supervisor.

Abstract

A simple and fast pre-column derivatization High Performance liquid Chromatographic method for the analysis of Mancozeb technical was developed and validated in the present study. The mobile phase consist a mixture of Acetonitrile and 0.1% (v/v) formic acid in the proportion 60:40. This was found to give sharp peak of S-ethyl derivative of Mancozeb (S-ethyl ethylenebisdithiocarbamate) at a retention time of 9.12 minutes. HPLC analysis of Mancozeb was carried out at a wave length of 272 nm with a flow rate of 1.0 mL / minute. The linear regression analysis data for the calibration curve showed a good linear relationship with a regression coefficient 0.999 in the concentration range of 8.2 mg/L to 32.3 mg/L for derivative of Mancozeb technical. The method was validated for specificity, linearity, precision and accuracy.

Biography

Dr. Mustafa Tuzen is Professor in Chemistry Department, Gaziosmanpasa University in Turkey. He administrated seven masters and five doctoral theses under his supervision. He completed several national and international projects. He is member of Turkish Academy and Sciences. He is well known specialist in analytical environmental chemistry. He is working on analytical chemistry, trace element analysis, enrichment and separation, speciation analysis, adsorption, biosorption, green extraction techniques, sample preparation methods, microextraction of trace organic and inorganic species. He has got 243 paper in SCI journals, cited papers in SCI journals: 10316, H factor: 62 according to Web of Science.

Research Interests: Analytical chemistry, trace element analysis, enrichment and separation, speciation analysis, adsorption, biosorption, green extraction techniques, sample preparation methods, microextraction of trace organic and inorganic species

 

Abstract

Direct determination of traces analyte ions in water, food and environmental samples is restricted by two main difficulties. These are very low concentration of analyte ions, which may be lower than the detection limit of spectroscopic techniques and the interfering effects of the matrix components. These problems can be solve by using separation and enrichment methods. Microextraction techniques has recently attracted great interest in modern research due to its simplicity, cost effective, high efficiency and reduced exposure of toxic chemicals to the environment. In this presentation, various microextraction methods such as solid phase microextraction (SPME), magnetic SPME, dispersive liquid- liquid microextraction, solidified floating organic drop microextraction, ultrasound assisted ionic liquid dispersive microextraction, fibers, hallow fiber liquid phase microextraction, direct immersion, head space single drop microextraction, supramolecular solvent extraction, switchable solvents, deep eutectic solvent extractions (DESs) and its application will discussed. DESs are obtained by mixing two or more cheap and green components, including hydrogen bond donor and hydrogen bond acceptor, with the ability to relate to each other by hydrogen bond interactions. DESs are frequently achieved by means of generating complex of salt named choline chloride (Vitamin B4, ChCl) (e.g. inexpensive, nontoxic and biodegradable) through hydrogen bond donor (HBDs) or a metal salt (e.g. low-cost and green, sugars, glycerol and carboxylic acids). Separation and enrichment of organic and inorganic analytes will be discussed by using sensitive, selective and green extraction techniques (1-3).

References

  1. Naeemullah, Tuzen, M., Citak, D., Analytical Methods, 2016, 8, 2756-2763.

  2. Panhwar, A.H., Tuzen, M., Kazi, T.G., Talanta, 2018, 178, 588-593.

  3. Soylak, M., Unsal, Y.E., Tuzen, M., Food and Chemical Toxicology 2011, 49, 1183-1187.

Biography

Manvendra Singh Kaurav pursuing Ph.D. at the department of School of studies in Chemistry, Jiwaji University, Gwalior and received his M.Sc. from the Dept. of School of studies in Industrial Chemistry, Jiwaji University Gwalior in 2012. In 2014, after qualifying General Aptitude Test of engineering (GATE – a national level Test) he joined as a Junior Research fellow at the School of Basic Sciences, IIT Bhubaneswar, India. His research focuses on the target &amp; diversity oriented synthesis of bioactive natural products and natural products inspired scaffolds. In the year of 2016-2017 Received Scholarship as a JRF from IIT Bhubaneswar

Research Interests: Multicomponent Synthesis of heterocyclic compounds, NP’s synthesis and Separation/Isolation of API’s from crude.

 

Abstract

As all we know that theoretically we can’t separate everything, but experimentally “we can!” in the era where everyone wants quality in quantity. We as a chemist performed experiments and produce results for the betterment of human being. Since past purification was the big issue, so we can developed so many techniques and separation is one of them where we get almost pure form of our desired products in both qualitative and quantitave manner if we go precisely. Separation of mixture could be possible by physical or chemical process and now we are in advanced stage where we also used electrical instruments for separation. In the synthesis of Medicinal drugs and Biologically Active Natural Products (NP’s); Active Pharmaceutical ingredients (API’s) plays vital role, and they are separated from medicinal plants by the use of different kinds of separation techniques like Maceration, Boiling, filtration, Distillation and extraction, where we use various solvents (like MeOH, EtOH, Acetone, THF, DCM etc.) further purification of them also required in some case because they are have more impurities. Silica Based Chromatographic techniques like; Thin Layer chromatography (TLC), Column chromatography, Gas Chromatography (GC), HPLC etc. are used for separation

Day2: July 6, 2018

Keynote Forum

Biography

Tracy Bantegui is a Senior Applications Scientist for Cerahelix, Inc, where she directs laboratory studies with outside research institutes and industrial customers. These collaborative studies apply the Cerahelix ceramic NF technology for use in high recovery wastewater projects as well as application in organic solvent nanofiltration. Prior to Cerahelix, Ms. Bantegui worked as an analytical chemist and inorganic chemistry section supervisor for the Health & Environmental Testing Laboratory within the State of Maine’s Center for Disease Control. Ms. Bantegui has B.S. degrees in both Chemistry and Biology from Husson University located in Bangor, Maine.

Research Interests:

Surface modification of inorganic membranes for enhanced separation

Abstract

Nanofiltration (NF) is typically associated with non-porous polymeric membranes where permeate diffuses through the polymeric material. Ceramic membranes, however, are porous and separate based on size separation typically in the microfiltration or ultrafiltration regime. Use of a DNA-template has resulted in ceramic membranes capable of separating in the tight NF region. The DNA template process creates pore structures that are continuous, linear, highly aligned, and with a very narrow size distribution (0.6- 0.8nm). The result is a ceramic membrane that can separate particles not just by size but also based on charge. For example, this membrane has demonstrated >90% removal of dissolved solids including phosphate, sulfate, and hardness minerals. This ceramic NF combines the advantages of the thermal stability and chemical inertness of ceramic materials with reduced irreversible membrane fouling and thus reduced flux decline, thus enabling process innovation around ceramic NF. Electrocoagulation (EC) coupled with ceramic NF is one such innovative process solution. The ceramic NF can withstand the by-products of the EC process while simultaneously enhancing EC efficiency. Together, this results in >97% hydraulic recovery. Recent data in a dairy wastewater application showed >90% reduction in TSS, COD, nutrients, and hardness minerals. This robust platform technology is ideally suited for treat-to-reuse applications.

Biography

Fawzi Banat is a Professor & Chair of Chemical Engineering Department at Khalifa University of Science and Technology, Petroleum Institute. Obtained PhD (Chemical Engineering) at McGill University, Canada, in 1995. He received several research awards and published over 140 papers and holds a number of international patents.
 
Research Interests:
wastewater treatment, membrane technology, desalination and separation processes.

 

Abstract

An environmentally friendly and economically effective surfactant modified porous graphitic carbon (S-PGC) was successfully fabricated to be used as a high efficiency sorbent for removing organic dyes from simulated water samples. The novel adsorbents prepared by pre-treating the porous graphitic carbon (PGC) prepared from alginate biomass using conventional anionic surfactants such as sodium dodecyl sulfate (SDS) and sodium dodecyl benzene sulfonate (SDBS) exhibited excellent adsorption performance for removal of cationic organic dyes such as methylene blue (MB), methyl violet (MV) and methyl yellow (MO). As compared to PGC of meso and microporous character, the developed S-PGC adsorbent achieved excellent adsorption capacities (>90%) and faster adsorption kinetics for the elimination of organic dyes even at very high dye concentrations of 1000 mg/L. Anchoring of the surfactant on the surface of the graphitic carbon is believed to improve its affinity towards the dyes owing to the narrowing of the pore opening and existence of abundant hydroxyl, ether and amine groups. Based on the high efficiency, feasibility and recyclability, surfactant modified graphitic carbon prepared from alginate biomass exhibits a great potential for water purification.
 

Tracks

  • Analytical Chemistry | Mass Spectrometry | Spectroscopic Methods in Separation Techniques | Separation Techniques and Applications | Membrane Separation Techniques
Location: Sylt 4-5
Speaker

Jonathan W Cooper

National Institute of Health, USA

Chair

Speaker

Miloš Netopilík

Institute of Macromolecular Chemistry AS CR, Czech Republic

Co Chair

Biography

Dr. Yoram Oren is a Professor Emeritus of chemistry in the Zuckerberg Institute for Water Research at the Ben-Gurion University of the Negev, Israel. He was graduated at the Technion, Haifa, Israel, the Department of Chemistry and was awarded his MSc. And PhD. from the Weizmann Institute of Science. Between 2002 until his retirement on 2012 he served as the head of the Department for Desalination and Water Treatment at ZIWR. Prof. Oren is still fully active in research and teaching at ZIWR and abroad.

Research Interests: Reverse osmosis, nanofiltration, ultrafiltration for desalination and water treatment. Electrochemical processes for preserving the environment, surface phenomena, electrodialysis for water treatment and desalination, ion exchange membranes, electrochemical phenomena in pressure driven processes for water treatment (Reverse osmosis, nanofiltration), capacitive deionization, electrochemical aspects in biofouling of membranes for water treatment. Ion exchange membrane bioreactors for water decontamination.

Abstract

Electrodialysis (ED), an electrochemically driven membrane separation process, is considered an optional stage in the treatment chain of brackish water reverse osmosis (BWRO) brines to improve water recovery and to reach near-Zero Liquid Discharge (ZLD) conditions1, 2. However, using an integrated RO-ED process for ZLD requires managing mineral scaling by sparingly soluble salts such as CaSO4 and BaSO4, both present in brackish water. Scaling may result from the high concentrations evolving in the brine streams as well as from concentration polarization at the membrane–solution interface in the brine compartments. Mineral scaling results in a significant, often irreversible, increase of stack electrical and hydraulic resistances and, consequently resulting in a larger energy consumption. Calcium and barium sulfate scaling is studied at Donnan exchange3 and ED conditions4. Scaling and Non-scaling experiments have been conducted using both anion and cation exchange membranes with heterogeneous (MA-40 and MK-40) or homogeneous (AMV and CMV) structure. The effect of CaSO4 scaling on membrane performance is expressed in terms of sulfate-flux decline due to membrane blocking by scale, membrane potential changes, stack total resistance changes and water splitting extent. Effects of current density, membrane type and hydrodynamic conditions on scaling extent are discussed. Figure 1 shows examples of SEM images of CaSO4-scaled anion-exchange membranes.

A

B

Figure 1. SEM images of CaSO4-scaled: A) MA-40 and B) AMV membranes

References

  1. Y. Oren et al., Pilot studies on high recovery BWRO-EDR for near zero liquid discharge approach, Desalination 261 (2010) 321.
  2. E. Korngold et al., Electrodialysis of brine solutions discharged from an RO plant, Desalination 242 (2009) 215.
  3. M. Asraf-Snir, J. Gilron, Y. Oren, Gypsum Scaling on Anion Exchange Membranes during Donnan Exchange. J. Membr. Sci. 455 (2014) 384.
  4. M. Asraf-Snir, J. Gilron, Y. Oren. "Gypsum Scaling of Anion Exchange Membranes in Electrodialysis", Journal of Membrane Science 520 (2016) 176–186

Biography

Axel Vansteene, PhD Student at CEA Saclay, grew up in France and received both a Bachelor's degree from Paris Chemistry Engineering School and a Bachelor’s degree in nuclear engineering from INSTN in 2015. Before his graduation, he joined Reiner’s Lab at Memorial Sloan-Kettering Cancer Centre in New York, in order to develop radioactive tumor tracers for PET imaging. He joined Mariet’s Microfluidics Lab in November 2015, to pursue a PhD thesis in the development of microsystems for the liquid-liquid extraction of radioactive compounds.

Research Interests:

Radiochemistry, liquid-liquid extraction, microfluidics, Computational Fluid Dynamics (CFD)

Abstract

Techniques devoted to liquid-liquid extraction kinetics studies have seen a tremendous development in the last decades. Various contactors, including Lewis-type cells, moving drops, and Rotating Membrane Cells (RMC) are used. However, these standard methods suffer from major drawbacks, i.e. poor definition of the diffusing films thickness at the liquid-liquid interface 1, large volumes of solvents and reagents needed, and potential effect of the membrane in RMC technique. In order to decrease the manipulated quantities of reagents and control accurately the specific interfacial area, segmented flow in microsystems were investigated as a new tool to determine kinetics of liquid-liquid extraction. Indeed, internal mixing of the solutes and complexes within the dispersed and continuous phases is ensured by both diffusion at small scale (microchannels width < 100 μm) and recirculation circles2. Therefore, the kinetics of the extraction of a well-known chemical system (Eu(III) by the N,N’-dimethyl N,N’-dibutyl tetradecylmalonamide, in nitric media) was studied. The determined value of pseudo-kinetic mass transfer coefficient K (m.s-1) is in good agreement with the values obtained with standard techniques, including Nitsch cell3and RMC4. Then, the use of segmented flow microfluidics should therefore be considered in the future of liquid-liquid extraction kinetics studies.

References:

  • Danesi, P. R., Solvent Extraction Kinetics. In Solvent Extraction Principles and Practice, New York, 2004; pp 203-251.
  • Burns, J. R.; Ramshaw, C., The intensification of rapid reactions in multiphase systems using slug flow in capillaries. Lab Chip 2001, 1 (1), 10-5.
  • Weigl, M.; Geist, A.; Gompper, K.; Kim, J.-I., Kinetics of Lanthanide/Actinide Co-Extraction with N,N′-Dimethyl-N,N′-Dibutyltetradecylmalonic Diamide (Dmdbtdma). Solvent Extraction and Ion Exchange 2001, 19 (2), 215-229.
  • Simonin, J. P.; Perrigaud, L.; Perrigaud, K.; Vu, T., Kinetics of Liquid/Liquid Extraction of Europium(III) Cation by Two Malonic Diamides. Solvent Extraction and Ion Exchange 2014, 32 (4), 365-377.

Biography

Dr. María Ramos Payán has completed her PhD from University of Seville, Spain and postdoctoral studies from University of Copenhagen (Denmark), University of North Carolina (USA) and Microelectronic National Center of Barcelona (Spain). She is leader of the microfluidic research line. She has published more than 30 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract

Sample treatment is the most important step previous real sample analysis. This procedure have been developed in order to improve the existing methodologies and offer new advantages. A step forward in this topic has been achieved with the miniaturized LE as Liquid phase microextraction (LPME), where the extraction of the analytes is controlled by passive diffusion [1] and as Electromembrane Extraction (EME) where the extraction procedure is controlled by an electrical field force [2]. Both techniques have been optimized in microfluidic systems, however, compared to traditional LPME and EME, there are other parameters to take into account when miniaturized systems are used. Based on the literature, traditional EME seemed to offer higher extractions efficiencies than traditional LPME when both were carries out using the same set-up. When LPME and EME are miniaturized into microfluidic systems, the geometry and the depth of the channels are critical for the performance. Since any of those techniques use agitation during extraction, the depth of the channel must be carefully optimized in order to get better extraction efficiencies. EME procedures require the use of a platinium electrode in each channel so, consequentely, the depth of the channel must be a bit deeper than the i.d of the electrode. However, LPME channels can be much less deeper since it works under passive diffusion and the distance between the analyte of interest and the SLM decrease. For this reason, in miniaturized systems, an exhaustive study of the channel size must be carried out since the extraction efficiencies are not always higher using EME than LPME, although the first one use an electrical field to accelerate the electromigration. 

Image

References

[1] G. Helle, C. Mariet, G. Cote, Micro  fluidic Tools for the Liquid-liquid extraction of radionuclides in analytical procedures, Procedia Chem. 7 (2012) 679-684.

[2] M. Rezazadeh, Y. Yamini, S. Seidi, B. Ebrahimpour, Electromembrane surrounded solid phase microextraction: a novel approach for efficient extraction from complicated matrices, J. Chromatogr. A 1280 (2013) 16-22.

Acknowledgements

This work was supported by the Grant Juan de la Cierva-Incorporación (Ministry of Economy, industry and competitiveness), Grant number JCI-2015-26647.

Biography

Saoussen Hammami is lecturer of Lecturer of Organic Chemistry, Faculty of Sciences of Monastir, Tunisia. She has published many papers in International Peer Reviewed Journals. Her current research work is dealing with chemical investigation of crude extracts from medicinal plants and marine organisms and with structure elucidation of pure natural products via 2D NMR and MS experiments

Research Interests: Chromatography, Mass Spectrometry, Organic Synthesis, High-Performance Liquid Chromatography, Liquid Chromatography, Synthetic Organic Chemistry, Medicinal and Pharmaceutical Chemistry, Extraction, Spectrometry, Antioxidant Activity

Abstract

The biodiversity of the Mediterranean basin ecosystem is the most prolific sources of plant metabolites playing a pivotal role as starting precursors for drug discovery [1]. Tunisia has nearly 2100 vascular plant species, many of which are endemic, widely used for traditional health care and still largely unexplored [2]. As a part of our contribution to the discovery of new secondary metabolites with potent biological activities [3-5], we have been interested to the chemical and biological sudies of the crude extracts of some medicinal plants from Apiaceae family. In this subject, the phytochemical investigation of the dichloromethanoic extract of Daucus virgatus, led to the isolation and identification of three new sesquiterpenoids. Their structures were elucidated by means of modern spectroscopic techniques such as 1 and 2D NMR and HR-ESIMS. All compound were evaluated for the antiproliferative effects against the melanoma cell line A375, the human breast adenocarcinoma cell line MCF-7, and the non-tumor cell lnes HACAT (Keratinocyte). Interesting selective activities were unveiled.

Day3: July 7, 2018

Keynote Forum

Biography

Miloš Netopilík has completed his PhD at the age of 30 years from Institute of Macromolecular Chemistry and postdoctoral studies from Virginia Polytechnic Institute and Technical University. Now, he works in Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic and works in the theory of separation. He has published more than 68 papers in reputed journals.

Research Interests: separation mechanism, SEC with multiple detection

 

Abstract

The equilibrium model is based on the concept of theoretical plate on which the equilibrium is formed between molecules of the analyte moving together with MP and those anchored on the surface by enthalpic attractive forces or penetrated into the pores by entropic process basically of Brownian diffusion into pores of the stationary phase (SP). However, the flow-rate, necessary to reach a good resolution, is by far lower than one would expect from that, necessary to reach a good equilibrium. Two kinetic processes, viz., tortuous and obstructed flow of eluent through and around the particles of packing and the flow profile in the mobile phase whose dispersive effect is controlled by transverse diffusion, may combine to reduce band broadening (imperfect resolution). To avoid it, the individual molecule has to sample the complete range of linear flow velocities in a random way as it moves along the column; this is achieved by transverse diffusion. This is shown on analyses of several polystyrene standards.

 

Biography

Prof. Xindu Geng graduated from Northwest University (NWU, Xi’an) and became a Faculty Member of Department of Chemistry of NWU, and then a Faculty Member University of Minnesota in 1982~1983; Visiting Professor of Purdue University separately at Department of Biochemistry in 1982~1984 and Department of Chemistry in 1995~1996, as well a Visiting Professor of Chemistry Department of Creighton University in 2001. He is the director of Institute of Modern Separation Science of Northwest University. He has published more than 300 papers in reputed journals, four books, and thus won 2 awards in National Scientific and Technology Rank of China; 5 awards in first rank of Provincial and States in China.

Research Interests:

Interest Research Fields: Theory and applications of separation science mainly for stoichiometric displacement theory and unified adsorption mechanism of solute from solution in surface of chemistry; fast separation and purification of biopolymers by liquid chromatography, instrumentation, especially for protein drugs in biotechnology and protein folding liquid chromatography; synthesis of multiple-functional separation media in separation technology; protein interactions on solid-liquid interface.

 

Abstract

Resolution of substance separation by liquid chromatography (LC) has been based on thermodynamic parameter of partition coefficient of the substance by keeping dynamic factor as constant, resulting in LC to greatly contribute to pure and applied sciences. However, many problems appear in practice, such as vague nomenclature of irregular sample, hidden, overlapping peptide peaks, and so on. The purpose of the presentation is to explore a new approach for solving these problems by dynamic separation with a minor-adjustment of the retention of peptides, induced by varying the mobile phase flow-rate (MPF-R). The retention characteristics of peptides under gradient elution in RPLC was firstly found to be dominated by two variables of the steady region (SR) and migration region (MR). The changes in peptide retention induced by varying the MPF-R can be attributed to changes in the rate of bond breaking of multiple molecular interactions of peptides from the SR and of the mass transfer of peptides from the stationary phase to the mobile phase in the MR. The two dynamic variables were also found to independently depend on the type of peptide. Desirable results were obtained using six standard oligopeptides and a real sample of trypsin-digested lysozyme. It is expected that the quality control of peptide drugs, high dispersion of peptide peaks in peptide mapping and “bottom”.

 

Tracks

  • Separation Techniques in Clinical/Pharmaceutical Chemistry | Separation Techniques in Chemical Engineering | New Instrumentation and Multidimensional Separations | Separation Techniques in Organic Chemistry | Separation Techniques used in Nanotechnology
Location: Sylt 4-5
Speaker

Tracy Bantegui

Cerahelix Inc, USA

Chair

Speaker

Martin Schimpf

Boise State University, USA

Co Chair

Biography

Professor Yuan is the dean of materials and chemical engineering institute in Quanzhou Normal University. He is the director of Engineering Research Center of Seawater Utilization Technology of Ministry of Education, and Hebei Collaborative Innovation Center of Modern Marine Chemical Technology. He had directed and completed 1 International Cooperation Project, 5 Scientific Research Project at nation level, 4 Provincial and Ministerial Project, 20 other Key Project, and other Industrial Project more than 30. He has been prized ‘National Science Technology Invention third class’, the first class at provincial level once, and the second class at provincial level twice. Meanwhile, he has published more than 110 academic papers and 24 issued patents.

Research Interests:

Professor Yuan’s research interests embrace various aspects of seawater resources utilization and environmental protection. The focus of his current research is on seawater decalcification, extraction of potassium from seawater, CO2 capture, mineral carbonation, seawater desulfuration, electrodialysis, nanofiltration, ultrafiltration and the treatment of flue gas, the treatment of wastewater and garbage.

Abstract

The large-scale emission of concentrated seawater, which is the by-product of seawater desalination process, has drawn worldwide attention for its potential threat to the marine ecological environment. In this paper, the preparation of aqueous sodium chloride solution from concentrated seawater by nanofiltration and selective electrodialysis were conducted with  1000m3/d and 300m3/d demonstration projects respectively, and the optimized operating conditions were achieved with high liquid salt quality and low power consumption. In the test of the concentrated seawater treatment by nanofiltration, the effects of influent flow, brine recovery, and operating pressure on ion rejection, sodium chloride recovery, and energy consumption were investigated, and a continuous operation test of 1000m3/d pilot was performed. The results show that the rejection rates of SO42-, Mg2+, and Ca2+ can reach 99.5%, 97.0%, and 86.0%, respectively, that is, the total concentration of impurities in the liquid salt decreases from 5.82 g/L to 0.14 g/L. The power consumption is 1.8 kWh/m3, and the total recovery of sodium chloride reaches 59%. In the test of the concentrated seawater treatment using selective electrodialysis, the influence of voltage, concentration of sodium chloride in liquid salt on recovery of sodium chloride and the electricity consumption are investigated, and the continuous operation test of the 300m3/d pilot was conducted. The results indicate that when the NaCl concentration in the liquid salt is concentrated from 35.0 g/L to 180.6 g/L and the NaCl recovery is 50.0%, the power consumption is only 195.9 kWh/t (100% NaCl).

Biography

Doctor Zhao is the associate professor of Hebei University of Technology. She previously studied at Tianjin University (China) from 2007.09 to 2012.01 and during this period she had been to the University of Western Ontario (Canada) at Department of Chemical and Biochemical Engineering as a visiting scholar from 2010.08 to 2011.08. Now, she is the department head of marine technology at Hebei University of Technology. From 2012 to now, she has directed 1 Scientific Research Project at nation level, 4 Provincial and Ministerial Project, 1 other Key Project, and 2 other Industrial Project. And she has participated in 4 Scientific Research Project at nation level, 1 Provincial and Ministerial Project, 2 other Key Project, and 1 other Industrial Project. Meanwhile, she has published 5 issued patents and more than 20 academic papers with the citation frequency more than 50.

Research Interests:

Associate professor Zhao’s research interests in seawater resources utilization and environmental protection. The focus of her current research is on seawater decalcification, extraction of potassium from seawater, CO2 capture, mineral carbonation, seawater desulfuration, separation technology of inorganic salts, and industrial crystallization.

Abstract

This study promotes a two-step accelerated mineral carbonation technology at moderate temperature and atmospheric pressure, by choosing the problematic ions for seawater utilization as mineralizers, that is, Ca2+ as the first mineralizer and Mg2+ in the residual solution as the second. Therefore, not only carbonate ions generated from the absorption and ionization of CO2 can be fixed by Ca2+ through first carbonation process with the added alkali source MgO, but also HCO3- in the residual solution can be mineralized by Mg2+ through second carbonation process with the added NaOH. Meanwhile, pure CaCO3 and MgCO3·3H2O with possible beneficial reuse can be obtained as by-products. Moreover, softened water is beneficial for long-term stable equipment operation, energy saving and the reduction of economic cost for the following desalination. The corresponding mechanism for first carbonation by ionizing magnesia was presumed according to ions concentration changes, precipitants conversion. Then more variables were set to optimize technical conditions. Under the optimum condition, decalcification rate can reach above 92.0%, carbon sequestration changes from 30% and 50%, and the reaction time is only 10 mins with pure CaCO3 as by-product. In the second carbonation process, the carbonation of residual HCO3- by Mg2+ was realized by adding NaOH, and the magnesium extraction can reach about 75% with pure MgCO3·3H2O as another by-product.

Biography

A simple and fast pre-column derivatization High Performance liquid Chromatographic method for the analysis of Mancozeb technical was developed and validated in the present study. The mobile phase consist a mixture of Acetonitrile and 0.1% (v/v) formic acid in the proportion 60:40. This was found to give sharp peak of S-ethyl derivative of Mancozeb (S-ethyl ethylenebisdithiocarbamate) at a retention time of 9.12 minutes. HPLC analysis of Mancozeb was carried out at a wave length of 272 nm with a flow rate of 1.0 mL / minute. The linear regression analysis data for the calibration curve showed a good linear relationship with a regression coefficient 0.999 in the concentration range of 8.2 mg/L to 32.3 mg/L for derivative of Mancozeb technical. The method was validated for specificity, linearity, precision and accuracy.

Abstract

Mr. N. H. Petha is pursuing his doctoral work at Jaipur National University. He has more than 10 years of analytical research experience in Pharmaceuticals, Agrochemicals and Specialty Chemicals and currently working in Analytical Development Laboratory of Indofil Industries Limited.

Research Interests:

Analytical research in industrial challenges to benefit society at large.